A synthesis of 2-(substituted phenyl)-propionic acid. II. An alternate synthesis of 2-(4-isobutylphenyl)-propionic acid.
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چکیده
منابع مشابه
Synthesis and biological evaluation of new 1,3-thiazolidine-4-one derivatives of 2-(4-isobutylphenyl)propionic acid.
New thiazolidine-4-one derivatives of 2-(4-isobutylphenyl)propionic acid (ibuprofen) have been synthesized as potential anti-inflammatory drugs. The structure of the new compounds was proved using spectral methods (FR-IR, 1H-NMR, 13C-NMR, MS). The in vitro antioxidant potential of the synthesized compounds was evaluated according to the total antioxidant activity, the DPPH and ABTS radical scav...
متن کامل2-[(4-Methylbenzoyl)hydrazono]propionic acid monohydrate
In the title compound, C(11)H(12)N(2)O(3)·H(2)O, the water mol-ecule is a hydrogen-bond donor to the double-bond amide and the carbonyl O atoms of two acid mol-ecules; it is also a hydrogen-bond acceptor to the acid -OH and amide -NH- groups. These hydrogen-bonding inter-actions give rise to a layer structure, with the layers parallel to the ab plane.
متن کامل2-[(4-Chlorobenzoyl)hydrazono]propionic acid monohydrate
In the title compound, C(10)H(9)ClN(2)O(3)·H(2)O, the water mol-ecule is a hydrogen-bond donor to the amide and carbonyl O atoms of two acid mol-ecules; it is also a hydrogen-bond acceptor to the acid OH group and the amide H atom. The hydrogen-bonding inter-actions give rise to a two-dimensional array.
متن کاملSynthesis of 2-(4-sec-butyl-phenyl)-propionic Acid- Pyrrolidin-2-ylcarbamoyl Methyl Ester Derivatives as Anti-inflammatory Potential
Synthesis of 2-(4-sec-butyl-phenyl)-propionic acid-pyrrolidin-2-ylcarbamoyl methyl ester with bio-isosteric concept for ibuprofen with enhancing anti-inflammatory potential. Ibuprofen on refluxing with 2-amino pyridine in chloroacetyl chloride in presence of glacial acetic acid gave 2-(4-sec-butyl-phenyl)-propionic acid-pyrrolidin-2-yl-carbamoyl methyl ester, which can be used as a prodrug for ...
متن کامل3-(4-Methoxybenzoyl)propionic acid
In the crystal of the title compound, C(11)H(12)O(4), inversion dimers arise from pairs of intermolecular O-H⋯O hydrogen bonds and C-H⋯O bonds further consolidate the packing. There is also a C-H⋯π contact between the benzene ring and the methyl-ene group.
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ژورنال
عنوان ژورنال: Agricultural and Biological Chemistry
سال: 1976
ISSN: 0002-1369,1881-1280
DOI: 10.1271/bbb1961.40.291